COMPANY
Our client is a biopharmaceutical company applying its’ discoveries in human genetics to the development of drugs and diagnostics for common diseases. A global leader in gene discovery, the Company’s population approach and resources have enabled them to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer. In addition to leveraging their capabilities for proprietary product development programs, they provide services in genotyping, structural biology, drug discovery and development and clinical development to pharmaceutical and biotechnology companies. Their services range from early-stage discovery and optimization to identification of viable synthetic routes required to manufacture cGMP material in quantities for pre-clinical and clinical studies. The Company’s Chemistry & Biostructures division conducts drug discovery and development for pharmaceutical and biotechnology companies using an integrated platform of structural biology and chemistry technologies. Their collaborations are designed to help clients to focus their resources on developing small molecule therapeutics that have the greatest promise of efficacy, selectivity, and safety in the clinic.

ENVIRONMENT
The Company’s modern facilities include state-of-the-art research, development, testing, production, customer support and sales & marketing operations. The Company takes a unique and comprehensive approach to drug discovery partnerships and offers a full range of drug discovery solutions for selecting high-quality drug candidates quickly and advancing drug development programs into the clinic through an integrated lead optimization approach that identifies candidate compounds that are potent against and specific for virtually any target, as well as optimized for pharmaceutical properties.

The culture is open, team oriented and highly focused on applying its discoveries in human genetics to the development of drugs and diagnostics for common diseases. Candidates must be comfortable with the demands of driving a small company’s growth and be compatible with an entrepreneurial environment that requires a hands-on-approach.

REPORTING
Reports to the division’s President.

EDUCATION
Ph.D. in pharmaceutical sciences, pharmacology, or related discipline.

PERSONAL CHARACTERISTICS
A highly credible, high impact individual with impeccable integrity and professional discipline is essential. The successful candidate will be an independent minded, analytical thinker, with a fact based decision making style capable of persuading and building consensus. Candidates must possess strong analytical, organizational, presentation and communication skills. The ability to effect and implement change in the present while developing and building for the future is critical. They must have a strong desire to grow themselves and an organization. The person selected will have the ability to initiate and follow projects to completion, the flexibility to work well with others and the capability of commanding the respect of MDs, scientists, and the company’s R&D & Service personnel.

RESPONSIBILITIES
Responsible for design, management, and interpretation of studies to assess safety, PK, PD, and ADME properties of investigational therapeutic agents in pre-clinical development. Directly oversees the activities of in vitro predictive ADME functions. Manages non-GLP and GLP safety pharmacology and toxicology studies placed at external CROs.

Major Responsibilities include:

• Provide leadership on safety aspects of investigational agents at pre-clinical stage.
• Design and manage in vitro and in vivo studies related to toxicology, safety pharmacology, PK, PD, and viability of investigational agents, using in-house and third party resources.
• Evaluate relevant predictive ADME technologies and provide access to those deemed valuable, either through bringing the technology in-house, or sub-contracting to appropriate CROs.
• Assist in marketing and selling the above services to our client base to impact company revenue stream and profitability.
• Reviews internal controls to ensure proper responses within established time frames and guidelines.
• Proactively identifies clinical, development and market opportunities and makes recommendations for enhancements to processes, systems and procedures.
• Provides subject matter expertise for the department to ensure the accuracy of responses to inquiries.
• Drive cross-functional activities that are key to sales and marketing efforts.

REQUIREMENTS
Candidates should posses the following experience, abilities and attributes:

• Minimum 5 years experience in a related role at a pharmaceutical or biotechnology company, or minimum 10 years experience in a related role in an academic environment.
• Knowledgeable of current issues in drug safety evaluation, including in vitro and in vivo modeling, and the predictive power of these models relative to drug effects in humans.
• They must be able to understand the clinical application of drug discovery and have the skills to develop and articulate the technical and business issues of all development programs.
• Cross-functional project and process management experience.
• Effective communication and presentation skills.

DESIRED QUALITIES & DELIVERABLES
The Company is seeking a scientist with the experience, business acumen, drive and entrepreneurial spirit to support their collaborations and the growth of their Chemistry & Biostructures services.

• The ideal candidate will be analytical, well- organized, creative, critical thinker equally capable of tactical execution and driving results.
• The candidate selected will be an effective and persuasive communicator able to articulate unique ideas and perspectives
• The successful candidate will have the presence and integrity to command respect and the confidence and energy to be an effective change agent.
• The Company desires a leader with strong interpersonal and people management skills that engenders high expectations and performance.
  

COMPENSATION
The complete package will include a competitive base salary and incentives that include performance bonuses, stock options and an attractive benefits program.

CONTACT
Glines Associates
Mr. Larry Glines
39 South LaSalle Street, Suite 714
Chicago, IL 60603
312.580.0646
search@glinesassociates.com
www.glinesassociates.com